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Penile Cancer

Home / Men's Health Conditions / Penile Cancer

What is penile cancer?

Penile cancer is cancer that occurs in the penis, specifically on the foreskin, head (glans) or skin of the penile shaft. It is a different type of cancer to testicular cancer, which occurs in the testicles.

The most common form of penile cancer, affecting around 95% of people, is called squamous cell carcinoma and usually develops under the foreskin. Other forms of penile cancer can include:

  • skin cancers that occur on the penis – such as basal cell carcinoma and melanoma of the penis
  • penile sarcoma – a type of cancer that develops in the blood vessels, muscles or fat.

How common is penile cancer?

Penile cancer is considered rare – around 103 cases are diagnosed each year in Australia. It is more likely to occur in people aged over 50 and people who are uncircumcised, as it commonly affects the foreskin.

What are the causes of penile cancer?

While researchers still aren’t sure what causes penile cancer, there are some factors that are known to increase your risk. The known risk factors include:

  • Human papillomavirus
  • Being uncircumcised
  • Smoking
  • Being aged over 50
  • Having HIV/Aids
  • A history of exposure to ultraviolet (UV) radiation
  • Certain skin conditions, like psoriasis.

Remember that most people with these symptoms do not develop penile cancer. If you are experiencing any of the symptoms listed above, speak to your healthcare professional.

What causes penile cancer?

While researchers still aren’t sure what causes penile cancer, there are some factors that are known to increase your risk:

  • having human papillomavirus
  • being uncircumcised
  • smoking
  • being aged over 50
  • having HIV or AIDS
  • having a history of exposure to ultraviolet (UV) radiation
  • having certain skin conditions, like psoriasis.

Remember that most people with these symptoms do not develop penile cancer. If you are experiencing any of the symptoms listed above, speak to your health care professional.

What are the symptoms of penile cancer?

There are many different symptoms of penile cancer. The common symptoms may include:

  • a growth – an obvious growth or sore that doesn’t go away
  • a rash – a noticeable red patch of skin that doesn’t go away
  • skin changes – obvious changes in the colour or thickness of the skin on the penis or foreskin
  • bleeding – from the penis or under the foreskin
  • discharge – from under the foreskin 
  • a hard lump – felt under the foreskin 
  • lumps – felt in the groin
  • pain and swelling – felt in the shaft or tip of the penis. 

How is penile cancer diagnosed?

Penile cancer is diagnosed through a range of tests. If you have noticed any of the listed symptoms, your health care professional will refer you to a specialist, who will conduct the tests. These might include:

  • a biopsy (skin sample) – to check whether there are any cancerous cells in the skin of the penis and surrounding areas
  • an ultrasound – to look for signs of cancer using soundwaves
  • CT, MRI or PET scans – special scans that take images of the penis and surrounding areas to check for signs of tumours.

When your health care professional has the results of your tests, they can determine whether you have signs of penile cancer and develop a suitable treatment plan.

In Australia, screening is not recommended for penile cancer. However, if you have a known family history or genetic mutation, talk to your health care professional about yearly screening.

How is penile cancer treated?

Like other forms of cancer, penile cancer treatment is based on the severity and stage of your disease, the location of the cancer and whether it has spread to nearby organs. Treatment options include:

  • conservative treatments – topical creams, lasers
  • surgery – to remove the cancer
  • radiation therapy – to kill the cancerous cells using X-rays
  • chemotherapy – to kill the cancerous cells using medication.

Surgery to remove the cancer is the most common treatment for penile cancer. Reconstructive surgery later can help correct any changes to the penis.

Alternatively, you may need radiation therapy to destroy the cancer cells. Radiation is sometimes also used after surgery to treat residual cancer cells.

Some penile cancers that haven’t spread or are in the early stages may not need surgery. Other non-surgical treatment options for penile cancer include:

  • laser treatment – if the cancer is very small
  • photodynamic therapy – medication that is activated by light to kill cancer cells
  • liquid nitrogen – to freeze and kill cancer cells
  • topical chemotherapy – drugs that shrink or slow the cancer growth.

What can you do if you have penile cancer?

If you have received a penile cancer diagnosis, your medical team will give you a personalised treatment plan. It’s important to take the time to learn about your condition, treatments and future plan.

Connecting with other men who have penile cancer can help you to feel supported and not alone. Having a strong support network is very beneficial for your emotional wellbeing, cancer management and treatment outcomes.

Your St Vincent’s cancer and men’s health teams will support you every step of the way.

Due to the low occurrences of penile cancer, studies are limited. Speak with your healthcare professional team at St Vincent’s if you want to know more about research or would like to participate in clinical trials for penile cancer.

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